tert-Butyl 6-nitro-1H-indole-1-carboxylate → tert-Butyl 6-amino-2,3-dihydro-1H-indole-1-carboxylate

Participants

Reaction Steps

6-Nitro-indole-1-carboxylic acid t-butyl ester (1 eq) was dissolved in methanol (0.1M), to this solution was added palladium on carbon (0.1 eq) in methanol under nitrogen. A hydrogen atmosphere was then inserted and resulting mixture allowed to stir for 3 hours at room temperature. The reaction mixture was then filtered through celite and solvent removed in vacuo to afford 6-Amino-2,3-dihydro-indole-1-carboxylic acid t-butyl ester as a white solid. MS: MH+235

Provenance & Evidence