HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 21037135, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2,6-Difluorophenyl isothiocyanate | HCID 4031601 | — |
| Reactant | 4-(3-Amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid dimethylamide | HCID 21037290 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 21037135 | HCID 21037135 | — |
Reaction Steps
A solution of the 4-(3-Amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid dimethylamide (1 eq) in methanol was treated with 2,6-difluorophenylisothiocyanate (1 eq) and stirred overnight. To the reaction mixture, methyl iodide (1 eq) was added and stirred overnight at 60° C. The reaction was cooled down to room temperature, evaporated, and the residue purified by reverse phase HPLC. HPLC, 1.66 min; MS: MH+=424.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614330B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-66ddeba9c9d247b9a8c38f0cc9c319c0 |
| Source note | uspto-grants-2013_12 |