HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophosgene → 3-Phenoxyphenylisothiocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | 3-Phenoxyaniline | HCID 77135 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-Phenoxyphenylisothiocyanate | HCID 22041281 | — |
Reaction Steps
To a stirring solution of 3-phenoxyaniline (185 mg, 1.0 mmol) in acetone (4.0 mL) at 0° C. was added thiophosgene (0.23 mL, 3.0 mmol) and the resulting reaction maintained for 30 min. The reaction determined complete by TLC (4:1 hexane/EtOAc). The reaction was concentrated, azeotroped with toluene and taken on without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614330B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-5db60a5e706848e79e22001091fd081d |
| Source note | uspto-grants-2013_12 |