HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-chloro-1-methyl-4-nitro-1H-pyrazole → HCID 86679972, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-chloro-1-methyl-4-nitro-1H-pyrazole | HCID 12344836 | — |
| Reactant | tert-Butyl (3S)-3-ethylpiperazine-1-carboxylate | HCID 24820542 | — |
| Product | HCID 86679972 | HCID 86679972 | — |
Reaction Steps
Following the procedure for Intermediate 10 starting from 5-chloro-1-methyl-4-nitro-1H-pyrazole from Example 1 and (S)-tert-butyl 3-ethylpiperazine-1-carboxylate gave (S)-tert-butyl 4-(4-amino-1-methyl-1H-pyrazol-5-yl)-3-ethylpiperazine-1-carboxylate as an orange gum (110 mg, 65% over two steps). LCMS (ES+) m/z 310 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08614206B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-2ff3a665b1054fed85504f28d1078040 |
| Source note | uspto-grants-2013_12 |