(R)-1-Boc-3-methylpiperazine → HCID 86679983, compound

Participants

Reaction Steps

Following the procedure for Intermediate 23 starting with 5-chloro-1-methyl-4-nitro-1H-pyrazole from Example 1 and (R)-tert-butyl 3-methyl-piperazine-1-carboxylate gave (R)-5-(2,4-dimethylpiperazin-1-yl)-1-methyl-1H-pyrazol-4-amine as a brown solid (94 mg, 62% over four steps). 1H NMR (400 MHz, CDCl3) δ 7.07 (s, 1H), 3.66 (s, 3H), 3.59-3.44 (m, 2H), 2.99-2.86 (m, 3H), 2.46-2.31 (m, 4H), 2.03 (t, J=10.7 Hz, 1H), 0.87 (d, J=6.3 Hz, 3H). Exchangeable NH2 not observed.

Provenance & Evidence