Potassium Carbonate → HCID 73602904, compound

Participants

Reaction Steps

(R)-3-amino-N-(1-(2,2-difluoroethyl)-5-(4-(2,2,2-trifluoroacetamido)azepan-1-yl)-1H-pyrazol-4-yl)-6-(2-fluorophenyl)picolinamide (98 mg, 0.17 mmol) was stirred with potassium carbonate (144 mg, 1.03 mmol) in methanol (5 mL) at 50° C. overnight. The mixture was filtered and the filtrate was purified on reversed phase HPLC to give 180. 1H NMR (400 MHz, DMSO) δ 9.81 (s, 1H), 8.00 (td, J=8.3, 1.8 Hz, 1H), 7.86 (s, 1H), 7.74 (dd, J=8.7, 2.2 Hz, 1H), 7.43 (dt, J=7.2, 3.8 Hz, 1H), 7.38-7.20 (m, 4H), 7.08 (s, 2H), 6.38 (tt, J=55.3, 4.1 Hz, 1H), 4.43 (td, J=14.5, 4.1 Hz, 2H), 3.55 (s, 1H), 3.21-3.07 (m, 4H), 2.92 (dd, J=19.4, 10.4 Hz, 1H), 1.89-1.69 (m, 3H), 1.69-1.37 (m, 3H). MS (ESI) m/z: 474.2 [M+H+].

Provenance & Evidence