HCID 73602996, compound → HCID 74983202, compound

HRID 1915918Notes

Reaction equation

NC1SC(C2C(F)=CC=CC=2F)=NC=1C(NC1C=NN(C)C=1N1CCC[C@H](NCC2COC2)CC1)=O.[O:37]1[CH2:40][CH:39]([CH2:41][N:42]([CH2:80][CH:81]2[CH2:84][O:83][CH2:82]2)[C@@H:43]2[CH2:49][CH2:48][CH2:47][N:46]([C:50]3[N:54]([CH3:55])[N:53]=[CH:52][C:51]=3[NH:56][C:57]([C:59]3[N:60]=[C:61]([C:72]4[C:77]([F:78])=[CH:76][CH:75]=[CH:74][C:73]=4[F:79])[S:62][C:63]=3[NH:64]C(=O)OC(C)(C)C)=[O:58])[CH2:45][CH2:44]2)[CH2:38]1>>[NH2:64][C:63]1[S:62][C:61]([C:72]2[C:73]([F:79])=[CH:74][CH:75]=[CH:76][C:77]=2[F:78])=[N:60][C:59]=1[C:57]([NH:56][C:51]1[CH:52]=[N:53][N:54]([CH3:55])[C:50]=1[N:46]1[CH2:47][CH2:48][CH2:49][C@H:43]([N:42]([CH2:80][CH:81]2[CH2:84][O:83][CH2:82]2)[CH2:41][CH:39]2[CH2:38][O:37][CH2:40]2)[CH2:44][CH2:45]1)=[O:58]

Participants

Reactant 2

HCID 73602996HCID 73602996, compound

HCID 89456695HCID 89456695, compound

Product 1

HCID 74983202HCID 74983202, compound

Procedure

In the preparation of 342, tert-butyl N-[4-[[5-[(4R)-4-[bis(oxetan-3-ylmethyl)amino]azepan-1-yl]-1-methyl-pyrazol-4-yl]carbamoyl]-2-(2,6-difluorophenyl)thiazol-5-yl]carbamate was deprotected following the procedure in Example 334 to give 343. LCMS (ES+) m/z 588 (M+1)

Sources & evidence

ORD record: ord-449e8c39bf304f37aade41b21a889063
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08614206B2

Reaction notes

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