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HRID1915950

反应详情

EQUATION

反应方程式

HRID 1915950 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2cccc(C#N)n2)OC1(C)C
HCID17750468

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile

C12H15BN2O2

结构：Cn1ncc(NC(=O)c2nc(Br)sc2NC(=O)OC(C)(C)C)c1N1CC[C@@H](NC(=O)OC(C)(C)C)CC(F)(F)C1
HCID86680147

未命名化合物

PRODUCTS

生成物

1
结构：Cn1ncc(NC(=O)c2nc(-c3cccc(C#N)n3)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1
HCID74983276

未命名化合物

PROCEDURE

实验过程

Following the procedures in Example 428, tert-butyl N-[2-bromo-4-[[5-[(5R)-5-(tert-butoxycarbonylamino)-3,3-difluoro-azepan-1-yl]-1-methyl-pyrazol-4-yl]carbamoyl]thiazol-5-yl]carbamate was reacted with 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile to give 461. LCMS (ES+) m/z 474 (M+1)