Lithium Hydroxide → HCID 86653392, compound

Participants

Reaction Steps

To 7 (927.1 mg, 0.850 mmol) in THF (12 mL) at 0° C. was added LiOH (30.6 mg, 1.28 mmol) in water (3 mL) and the reaction mixture was stirred for 3.25 h. The mixture was then quenched with 1M HCl (aq) (20 mL), diluted with water (20 mL), and treated with EtOAc (60 mL). The layers were separated, and the product was extracted with EtOAc (3×60 mL). The organic layers were combined, washed with saturated brine (50 mL), dried (MgSO4), and concentrated in vacuo to give the product 8 (789.1 mg, 86%) as a white solid (diastereoisomers 1:1 ratio). Compound 8 was used in the next step further purification [MS (ES+) 1097.4 (100%, [M+Na]+)].

Provenance & Evidence