Lithium Hydroxide → HCID 86653404, compound

Participants

Reaction Steps

To 4 (157.3 mg, 0.154 mmol) in THF (2.45 mL) at 0° C. was added LiOH (9.19 mg, 0.384 mmol) in water (0.65 mL) dropwise and the reaction was stirred for 55 min. The reaction mixture was then quenched with 1M HCl (aq) (10 mL) and diluted with water (10 mL). EtOAc (30 mL) was added the layers separated and the aqueous layer was extracted with EtOAc (3×30 mL). The organic layers were combined, washed with saturated brine (20 mL), separated, dried (MgSO4) and concentrated in vacuo to give 5 (153 mg, 0.154 mmol, 100%) as a white solid, which was used without further purification [MS (ES−) 959.2 (100%, [M−H]−)].

Provenance & Evidence