HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 4-Methyl-1,2-dithiolane-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Propanoic acid, 3,3-dichloro-2,2-dimethyl- | HCID 103039 | — |
| Reactant | Potassium ethanethioate | HCID 23670855 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Methyl-1,2-dithiolane-4-carboxylic acid | HCID 20069311 | — |
Reaction Steps
8 g of dichloropivalic acid are placed in a 250 ml three-necked flask on which are mounted a condenser and a dropping funnel. The acid is dissolved in 80 ml of water, and 4.6 g of Na2CO3 are slowly added. A solution of 10.7 g of potassium thioacetate is added dropwise, and the reaction medium is brought to reflux. 14.9 g of Na2CO3 are added and the medium is again refluxed. After disappearance of the starting material, 7.3 ml of DMSO are added, followed by refluxing. The dithiolane is obtained after acidification by precipitating and drying the solid under vacuum. A pale yellow solid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08617524B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-f96f56feecea45d791c77deec4322fcd |
| Source note | uspto-grants-2013_12 |