p-Toluenesulfonic acid → HCID 86648276, compound

Participants

Reaction Steps

To a solution of (E)-4-(4-(dimethoxymethyl)-3-methoxystyryl)benzonitrile (70 mg, 0.227 mmol) in aqueous THF (5 ml water/25 ml THF) was added p-toluenesulfonic acid (1 mg, 0.02 eq.) and the mixture was refluxed for 30 minutes. The mixture was concentrated under reduced pressure, extracted with EtOAc (3×), dried, and the solvent was removed in vacuum to give the desired product 99% pure by GC-MS. MS (EI+): 263 (100%, M+); 246 (40%), 232, 216, 203 (60%), 190 (65%), 176, 140, 88.

Provenance & Evidence