HCID 86235010, compound → HCID 131731106, compound

Participants

Reaction Steps

The compound was prepared according to the general Horner-Wittig methodology, from 4-formyl-2-methoxybenzaldehyde dimethylacetal (630 mg, 3 mmol), dimethyl-4-carbomethoxylbenzyl phosphonate (775 mg, 1 eq.) using tBuOK (404 mg, 1.2 eq.) as base in anhydrous THF (15 ml); the mixture was heated at 70 C for 90 minutes then worked up as described previously and purified by MPLC with hexanes/ethyl acetate 0-30% gradient. Yield: 795 mg (76%). MS, m/e: 342 (M+) 15%; 311 (M+-MeO, 100%); 294 (5%); 234 (4%); 164 (12%); 139 (10%).

Provenance & Evidence