Tetrahydrofuran → HCID 67480396, compound

Participants

Reaction Conditions

Reaction Steps

To a dry vial containing 4-formyl-2-methoxybenzaldehyde dimethylacetal (408 mg, 1.93 mmol) and diethyl-4-t-butoxycarbamoylbenzyl phosphonate (668 mg, 1 eq.) in THF (10 ml) was added potassium t-butoxide (265 mg, 1.2 eq.) in a glove box. The mixture was sealed under N2, heated to 70° C. and stirred at this temperature for 1 hr. To the cooled mixture was added triethylamine (0.5 ml), the crude product was diluted with ethyl acetate and adsorbed on silicagel. The product acetal was purified by MPLC using hexanes/ethyl acetate 10-60% gradient. MS (ESI+): 422 (M+23, M+Na+). Yield: 451.4 mg (66%).

Provenance & Evidence