HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1916025Generated: October 27, 2026
Hydrazine hydrate (1:1) → (1R,2R)-2-(4-chloro-phenyl)-cyclopropylamine
https://huagongshe.com/reaction/1916025
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-[2-(4-Chloro-phenyl)-cyclopropyl]-isoindole-1,3-dione | HCID 68410207 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (1R,2R)-2-(4-chloro-phenyl)-cyclopropylamine | HCID 39236201 | — |
Reaction Steps
A mixture of 2-[2-(4-chloro-phenyl)-cyclopropyl]-isoindole-1,3-dione (320 mg, 1.07 mmol) and hydrazine hydrate (0.5 ml) in ethanol (8 ml) was stirred for 0.5 hour at 50° C. The solution was evaporated under reduced pressure. The resulting amine (compound Z1.001) was used in example P1 without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618023B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-25836ee5066a40d6959776088b0fe1eb |
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| Source note | uspto-grants-2013_12 |
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