HCID 131731110, compound → HCID 131731111, compound

Participants

Reaction Steps

As shown in FIG. 7, [2-(8-Benzyloxy-imidazo[1,2-α]pyridin-3-yl)-1-(diethoxy-phosphoryl)-ethyl]-phosphonic acid diethyl ester 35 (Example 21) (1.5 g, 2.86 mmol) and ethanol (30 mL) were mixed in a 250-mL round bottomed flask and purged with nitrogen for 5 minutes. Palladium on carbon (10%, 50% wet, 1.5 g) was then added and the system purged for another 10 minutes. A balloon was then filled with hydrogen and attached to the reaction flask and the reaction allowed to proceed for 12 hours. The reaction mixture was then filtered through celite and concentrated under reduced pressure to afford 39. 860 mg, 72% yield. Dark yellow oil.

Provenance & Evidence