N-Iodosuccinimide → 2-Ethyl-3-iodoimidazo[1,2-a]pyridine

Participants

Reaction Steps

As shown in FIG. 8, N-iodosuccinimide (8.37 g, 57.25 mmol) was added to a solution of 2-ethyl-imidazo[1,2-α]pyridine 70 (Example 27) (12.88 g, 57.25 mmol) in dry acetonitrile (100 mL) at 0° C. The reaction was warmed to room temperature and then stirred for 12 hours. The mixture was then concentrated and purified on silica gel (CombiFlash, Heptane/EtOAc elution) to afford 2-ethyl-3-iodo-imidazo[1,2-α]pyridine 72, as photosensitive yellow crystals with a yield of 5.6 g, 35%.

Provenance & Evidence