Triethylamine → (S)-N-(1,4-dihydroxy-4-methylpentan-2-yl) morpholine-4-carboxamide

Participants

Reaction Conditions

Reaction Steps

(S)-2-amino-4-methylpentane-1,4-diol (0.6 g, 4.5 mmol) was dissolved in anhydrous dichloromethane (10 mL) and the solution was cooled to 0° C. Next, 4-morpholinecarbonyl chloride (0.78 mL, 6.75 mmol) was added, followed by triethylamine (0.75 mL, 5.4 mmol). The reaction was stirred for 3 hrs at 0-5° C. The solvent was evaporated and the residue was purified using silica gel chromatography (10% methanol-dichloromethane) to afford Cmpd 66. Yield: 0.675 g (61%). MS (m/z): (M+H)=247.

Provenance & Evidence