Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 6-(tert-butyl)phthalazin-1(2H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | 5-tert-Butyl-3-ethoxy-3H-isobenzofuran-1-one | HCID 58016209 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-(tert-butyl)phthalazin-1(2H)-one | HCID 57633933 | 92.3% |
반응 단계
2.9 g (12 mmol) of 5-tert-butyl-3-ethoxy-3H-isobenzofuran-1-one was weighed into a 50 mL round bottom flask fitted with a stir bar and cap. Added 10 mL (130 mmol) of hydrazine monohydrate. Added 15 mL of glacial acetic acid. Stirred at 100° overnight. Poured the reaction mixture into 200 mL of stirred water. Collected the solids by filtration and washed with water. Dried under high vacuum to obtain 2.24 g of the title compound as an off-white solid. MS (ESI) 203 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08618098B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-68cd45bbe99542db8bd02fc15ddb4dbd |
| 출처 메모 | uspto-grants-2013_12 |