Acetic Anhydride → 1-((S)-3-{3-[5-(2-Trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-ylamino}-pyrrolidin-1-yl)-ethanone

HRID 1916098Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][C@H:3]([NH:6][C:7]2[C:12]([C:13]3[N:14]=[C:15]4[CH:21]=[CH:20][N:19]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[C:16]4=[N:17][CH:18]=3)=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:2]1.[C:30](OC(=O)C)(=[O:32])[CH3:31]>>[CH3:27][Si:26]([CH3:29])([CH3:28])[CH2:25][CH2:24][O:23][CH2:22][N:19]1[C:16]2=[N:17][CH:18]=[C:13]([C:12]3[C:7]([NH:6][C@H:3]4[CH2:4][CH2:5][N:1]([C:30](=[O:32])[CH3:31])[CH2:2]4)=[N:8][CH:9]=[CH:10][CH:11]=3)[N:14]=[C:15]2[CH:21]=[CH:20]1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 69812480HCID 69812480, compound

Product 1

HCID 581774131-((S)-3-{3-[5-(2-Trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-ylamino}-pyrrolidin-1-yl)-ethanone

Procedure

1-((S)-3-{3-[5-(2-Trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-ylamino}-pyrrolidin-1-yl)-ethanone was prepared from (S)-pyrrolidin-3-yl-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine and acetic anhydride following the general synthetic procedures described in the above Examples.

Sources & evidence

ORD record: ord-4b02ba70c44e4944a4de82bd5095a161
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08618103B2

Reaction notes

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