Acetic Anhydride → HCID 58177394, compound

HRID 1916101Notes

Reaction equation

[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]([NH:8][C:9]2[C:14]([C:15]3[N:16]=[C:17]4[CH:23]=[CH:22][N:21]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:18]4=[N:19][CH:20]=3)=[CH:13][CH:12]=[CH:11][N:10]=2)[CH2:2]1.[C:32](OC(=O)C)(=[O:34])[CH3:33]>>[CH3:29][Si:28]([CH3:31])([CH3:30])[CH2:27][CH2:26][O:25][CH2:24][N:21]1[C:18]2=[N:19][CH:20]=[C:15]([C:14]3[C:9]([NH:8][CH:3]4[CH2:4][CH2:5][CH2:6][CH2:7][N:1]([C:32](=[O:34])[CH3:33])[CH2:2]4)=[N:10][CH:11]=[CH:12][CH:13]=3)[N:16]=[C:17]2[CH:23]=[CH:22]1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 69809870HCID 69809870, compound

Product 1

HCID 58177394HCID 58177394, compound

Procedure

1-(3-{3-[5-(2-Trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-ylamino}-azepan-1-yl)-ethanone was prepared from azepan-3-yl-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine and acetic anhydride, following the general synthetic procedures described in the above Examples.

Sources & evidence

ORD record: ord-89679fe321854b6d90d14fc70fc10d0a
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08618103B2

Reaction notes

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