HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Propanesulfonyl chloride → [(R)-1-(Propane-1-sulfonyl)-pyrrolidin-3-yl]-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Propanesulfonyl chloride | HCID 66279 | — |
| Reactant | (R)-pyrrolidin-3-yl-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine | HCID 69812726 | — |
| Product | [(R)-1-(Propane-1-sulfonyl)-pyrrolidin-3-yl]-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine | HCID 58177363 | — |
Reaction Steps
[(R)-1-(Propane-1-sulfonyl)-pyrrolidin-3-yl]-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine was prepared from (R)-pyrrolidin-3-yl-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine and propane-1-sulfonyl chloride, following the general synthetic procedures described in the above Examples.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618103B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-57cffc11fc2e445eb2ac0426d69f4eca |
| Source note | uspto-grants-2013_12 |