HRID1916111

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12933327

未命名化合物

结构：C[Si](C)(C)CCOCn1ccc2nc(-c3cccnc3N[C@@H]3CCNC3)cnc21

HCID69812726

未命名化合物

PRODUCTS

生成物

结构：CC(C)CCS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3c(ccn3COCC[Si](C)(C)C)n2)C1

HCID58177453

未命名化合物

PROCEDURE

实验过程

[(R)-1-(3-Methyl-butane-1-sulfonyl)-pyrrolidin-3-yl]-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine was prepared from (R)-pyrrolidin-3-yl-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyridin-2-yl}-amine and 3-methyl-butane-1-sulfonyl chloride, following the general synthetic procedures described in the above Examples.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-490304b68eec4c94b425186a847ef06c
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08618103B2
来源说明: uspto-grants-2013_12

反应 SMILES

[NH:1]1[CH2:5][CH2:4][C@@H:3]([NH:6][C:7]2[C:12]([C:13]3[N:14]=[C:15]4[CH:21]=[CH:20][N:19]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[C:16]4=[N:17][CH:18]=3)=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:2]1.[CH3:30][CH:31]([CH3:38])[CH2:32][CH2:33][S:34](Cl)(=[O:36])=[O:35]>>[CH3:30][CH:31]([CH3:38])[CH2:32][CH2:33][S:34]([N:1]1[CH2:5][CH2:4][C@@H:3]([NH:6][C:7]2[C:12]([C:13]3[N:14]=[C:15]4[CH:21]=[CH:20][N:19]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[C:16]4=[N:17][CH:18]=3)=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:2]1)(=[O:36])=[O:35]