Ammonium Hydroxide → HCID 131731114, compound

Participants

Reaction Conditions

Reaction Steps

In a 10 mL sealed tube {2-methanesulfonyl-5-[5-(2-trimethysilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyrimidin-4-yl}-[(S)-1-(2-methyl-propane-1-sulfonyl)-piperidin-3-yl]-amine (38 mg, 609 μmol) and ammonium hydroxide (450 mg, 0.5 ml, 12.8 mmol) were combined with 1,4-dioxane (2 ml) to give a light yellow solution. The reaction mixture was heated to 90° C. and stirred for 6 h. It was concentrated and diluted with water, extracted with ethyl acetate (2×20 ml). The organic layers were dried (MgSO4) and concentrated to give N*4*-[(S)-1-(2-methyl-propane-1-sulfonyl)-piperidin-3-yl]-5-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyrimidine-2,4-diamine as a yellow foaming solid. MS (ES+): 561.

Provenance & Evidence