Dimethylamine → HCID 58177237, compound

Participants

Reaction Steps

From {2-methanesulfonyl-5-[5-(2-trimethysilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyrimidin-4-yl}-[(S)-1-(2-methyl-propane-1-sulfonyl)-piperidin-3-yl]-amine derived from Example 3, step 1, dimethylamine was used to displace the methylsulfone similar to examples above and the de-protection step was similar to step 5 of Example 76 to give N*2*,N*2*-dimethyl-N*4*-[(S)-1-(2-methyl-propane-1-sulfonyl)-piperidin-3-yl]-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-pyrimidine-2,4-diamine. MS (ES+): 459.

Provenance & Evidence