Dimethyl Sulfone → HCID 69810608, compound

Participants

Reaction Steps

In a dioxane solution of {2-methanesulfonyl-5-[5-(2-trimethysilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyrimidin-4-yl}-[(S)-1-(2-methyl-propane-1-sulfonyl)-piperidin-3-yl]-amine from Example 3, step 1, morpholine was used to displace the methylsulfone similar to examples above and the de-protection step was similar to step 5 of Example 76 to give [(S)-1-(2-methyl-propane-1-sulfonyl)-piperidin-3-yl]-[2-morpholin-4-yl-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-pyrimidin-4-yl]-amine. MS (ES+): 501.

Provenance & Evidence