Ammonium Hydroxide → HCID 58177247, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of ((S)-1-methanesulfonyl-piperidin-3-yl)-{2-methanesulfonyl-5-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyrimidin-4-yl}-amine from Example 84, step 1 in ammonium hydroxide in dioxane was heated at 90° C. for 6 hours. The reaction was concentrated and diluted with water and extracted with EtOAc (2×20 ml). The organic layers were dried over MgSO4 and concentrated in vacuo to give a yellow foaming solid. MS (ES+): 561. The de-protection step was similar to step 5 of Example 76 to give N*4*-((S)-1-methanesulfonyl-piperidin-3-yl)-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-pyrimidine-2,4-diamine. MS (ES+): 389.

Provenance & Evidence