N-Iodosuccinimide → HCID 58177409, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ((S)-1-methanesulfonyl-piperidin-3-yl)-{2-methanesulfonyl-5-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyrimidin-4-yl}-amine derived from Example 84, step 1 (70 mg, 0.12 mmol) in acetone (0.5 ml) was treated with N-Iodosuccinimide (41 mg, 0.18 mmol) and stirred at 20° C. for 16 hours. The crude reaction mixture was concentrated in vacuo and was purified by silica gel chromatography (0% to 40% ethyl acetate/dichloromethane) to give 67 mg (79%) of {5-[7-Iodo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-2-methanesulfonyl-pyrimidin-4-yl}-((S)-1-methanesulfonyl-piperidin-3-yl)-amine. MS (ES+): 708.

Provenance & Evidence