Dimethylamine → HCID 50995153, compound

Participants

Reaction Steps

In a dioxane 2-[2-methanesulfonyl-4-((S)-1-methanesulfonyl-piperidin-3-ylamino)-pyrimidin-5-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonitrile derived from step 2 above, dimethylamine was used to displace the methylsulfone similar to examples above and the de-protection step was similar to Scheme 1, step 5 to give 2-[2-dimethylamino-4-((S)-1-methanesulfonyl-piperidin-3-ylamino)-pyrimidin-5-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carbonitrile. MS: (ES+): 442.

Provenance & Evidence