1,4-Dioxane--water (1/1) → HCID 178504938, compound

Participants

Reaction Steps

A solution of ((S)-1-methanesulfonyl-piperidin-3-yl)-[2-methoxy-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-pyrimidin-4-yl]-amine (18 mg, 0.044 mmol) from Example 84, step 1, in water/dioxane was heated to 105° C. for 16 hr. Solvent was evaporated and the product purified by super critical chromatography (SFC) to give 4-((S)-1-methanesulfonyl-piperidin-3-ylamino)-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-pyrimidin-2-ol. MS (ES+): 390.

Provenance & Evidence