Dimethyl Sulfone → HCID 69809288, compound

Participants

Reaction Steps

In a dioxane solution of ((S)-1-methanesulfonyl-piperidin-3-yl)-{2-methanesulfonyl-5-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyrimidin-4-yl}-amine derived from Example 84, step 1, Piperidin-4-yl-acetic acid was used to displace the methylsulfone similar to examples above and the de-protection step was similar to step 5, Example 76, to give {1-[4-((S)-1-Methanesulfonyl-piperidin-3-ylamino)-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-pyrimidin-2-yl]-piperidin-4-yl}-acetic acid. MS: (ES+): 515

Provenance & Evidence