Dimethyl Sulfone → HCID 69813333, compound

Participants

Reaction Steps

A solution of ((S)-1-methanesulfonyl-piperidin-3-yl)-{2-methanesulfonyl-5-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-pyrimidin-4-yl}-amine derived from Example 84, step 1, dimethyl-(R)-pyrrolidin-3-yl-amine was used to displace the methylsulfone similar to examples above and the de-protection step was similar to step 5, Example 76, to give [2-((R)-3-dimethylamino-pyrrolidin-1-yl)-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-pyrimidin-4-yl]-((S)-1-methanesulfonyl-piperidin-3-yl)-amine. MS (ES+): 486.

Provenance & Evidence