反应详情

Piperidine (20 g) and DMF (20 g) were mixed. To a quantity of this solution (20 ml, 18.08 g) in a sample vial was added dry resin (20 mg), and the suspension gently agitated by passage of a stream of argon. After 50 min, the resin was allowed to settle. An aliquot of solution (1 ml) was diluted 50-fold with ethanol, and the absorbance measured at 301 nM [(N-(9-fluorenylmethyl)piperidine UV λmax. 267 nM (ε 17500), 290 (5800) and 301 (7800)]. Two separate determinations (averaged) gave A301=0.0785. The following equation: [c (mmol/g)=(OD×50×102)/7800] gave c=0.50 mmol/g (Meienhofer et al. 1979).

1. customTwo separate determinations (averaged)