HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1916163Generated: October 30, 2026
Phosphorus oxychloride → 4-Chloro-5-iodo-6-methylpyrimidine
https://huagongshe.com/reaction/1916163
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-iodo-6-methyl-1H-pyrimidin-4-one | HCID 178433213 | — |
| Product | 4-Chloro-5-iodo-6-methylpyrimidine | HCID 12795369 | — |
Reaction Steps
A suspension of 90 g (0.38 mol) 4-hydroxy-5-iodo-6-methyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (90 g; 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618111B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-c26e4091181c4c0782e2c342503a9e4e |
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| Source note | uspto-grants-2013_12 |
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