N-Iodosuccinimide → HCID 57516727, compound

HRID 1916171Notes

Reaction equation

HRID 1916171 reaction equation
[F:1][C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][CH:7]=1.C1C(=O)N([I:16])C(=O)C1>>[F:1][C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[C:6]([I:16])[CH:7]=1

Participants

3

Reactant 2

HCID 120273N-IodosuccinimideHCID 27628092-Amino-3-fluoropyridine

Product 1

HCID 57516727HCID 57516727, compound

Procedure

The title compound is synthesized according to general procedure GP1 starting from 200 mg (1.78 mmol) 3-fluoro-pyridin-2ylamine and 401 mg (1.78 mmol) NIS. Yield after precipitation from the reaction mixture: 380 mg (90%).

Workup

  1. customYield
  2. customafter precipitation from the reaction mixture

Sources & evidence

ORD record
ord-40482c325b6b4237b05c4245636ac564
Source dataset
uspto-grants-2013_12
Patent number
US08618111B2

Reaction notes

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