HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Ethynylpyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(2-(Trimethylsilyl)ethynyl)pyridin-2-amine | HCID 22482858 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Ethynylpyridin-2-amine | HCID 21954827 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP3 starting from 5.5 g (29 mmol) 5-trimethylsilanylethynyl-pyridin-2-ylamine and 2.0 g (14 mmol) K2CO3 in 30 mL MeOH. The product is purified by chromatography on silica gel using a hexane/ethyl acetate gradient. Yield: 2.9 g (85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618111B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-8ee826a681ba42a8806f84eba9806648 |
| Source note | uspto-grants-2013_12 |