HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-ethynyl-N-methylpyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl-(5-trimethylsilanylethynyl-pyridin-2-yl)-amine | HCID 66705950 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-ethynyl-N-methylpyridin-2-amine | HCID 22663128 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP3 starting from 1.5 g (7.3 mmol) methyl-(5-trimethylsilanylethynyl-pyridin-2-yl)-amine and 507 mg (3.7 mmol) K2CO3 in 10 mL MeOH. Yield: 698 mg (56%) after chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618111B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-2b93ad93d24f422e9f55263ffae84176 |
| Source note | uspto-grants-2013_12 |