Lithium Hydroxide → HCID 58073746, compound

Participants

Reaction Conditions

Reaction Steps

The title compound is synthesized according to general procedure GP8 starting from 2.87 g (7.85 mmol) {1-[5-(6-amino-pyridin-3-ylethynyl)-6-methyl-pyrimidin-4-yl]-piperidin-4-yl}-acetic acid methyl ester using 0.82 g (19.6 mmoL) LiOH in 10 mL water and 40 mL THF. The reaction mixture is stirred over night at 50° C. The THF is removed under reduced pressure and the residue is taken up DCM and MeOH and separated from insoluble material. The filtrate is dried over MgSO4 and the solvent is removed under reduced pressure. After drying 2.9 g (95%) of crude product is obtained which is used for the next step without purification.

Provenance & Evidence