Hydrochloric Acid → HCID 58073732, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3.10 g (7.34 mmol) {1-[5-(6-amino-pyridin-3-ylethynyl)-6-methyl-pyrimidin-4-yl]-piperidin-4-ylmethyl}-carbamic acid tert-butyl ester in 20 mL DCM and 20 mL MeOH at RT is added 2.75 mL (11.0 mmol) 4 M HCl in dioxane. The reaction is to stirred over night at 50° C. The solvent is removed under reduced pressure and the residue is taken up in a small amount of MeOH. The precipitated product is filtered off and washed with few MeOH. After drying 3.06 g (95%) of the desired product is obtained.

Provenance & Evidence