HCID 66705985, compound → HCID 58073680, compound

Participants

Reaction Steps

A solution of 7.5 g (19.1 mmol) 4-[5-(6-Amino-pyridin-3-ylethynyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester in 50 mL 4 M HCl (in dioxane) ist to stirred for 3 hours at room temperature. The reaction mixture is evaporated and the residue is taken up in 50 ml DCM and washed with saturated aqueous NaHCO3 solution. After phase separation the organic solvent is removed under reduced pressure. The residue is taken up in methanol dried over Na2SO4. After 15 hours the suspension is filtered off, the residue is washed with methanol and the solvent is removed under reduced pressure. After drying 5.6 g (100%) of crude product are obtained, which are used without further purification in the next step.

Provenance & Evidence