Citric Acid → 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one citrate

HRID 1916232Notes

Reaction equation

HRID 1916232 reaction equation
[C:1]([OH:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4].[S:14]1[CH:18]=[CH:17][C:16]2[C:19]([N:23]3[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][CH2:31][CH2:32][O:33][C:34]4[CH:43]=[C:42]5[C:37]([CH:38]=[CH:39][C:40](=[O:44])[NH:41]5)=[CH:36][CH:35]=4)[CH2:25][CH2:24]3)=[CH:20][CH:21]=[CH:22][C:15]1=2>CO.ClCCl>[C:1]([OH:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4].[S:14]1[CH:18]=[CH:17][C:16]2[C:19]([N:23]3[CH2:24][CH2:25][N:26]([CH2:29][CH2:30][CH2:31][CH2:32][O:33][C:34]4[CH:43]=[C:42]5[C:37]([CH:38]=[CH:39][C:40](=[O:44])[NH:41]5)=[CH:36][CH:35]=4)[CH2:27][CH2:28]3)=[CH:20][CH:21]=[CH:22][C:15]1=2

Participants

5

Reactant 2

HCID 311Citric AcidHCID 11978813Brexpiprazole

Product 1

HCID 668859107-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one citrate

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

Citric acid was added to a solution of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one in methanol and dichloromethane and the solvent was evaporated under reduced pressure. The residue was recrystallized from 50% ethanol and thereby 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one citrate was obtained in the form of a white powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from 50% ethanol

Sources & evidence

ORD record
ord-8802d4a9614643d78570b114f905aafe
Source dataset
uspto-grants-2013_12
Patent number
US08618109B2

Reaction notes

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