2-Chloro-4,6-dimethylpyrimidine → HCID 59418303, compound

HRID 1916252Notes

Reaction equation

HRID 1916252 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.ClC1[N:16]=[CH:15][C:14]([CH3:17])=CN=1>>[NH:16]1[CH2:15][CH:14]([C:2]2[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=2)[CH2:17]1

Participants

3

Reactant 2

HCID 205502-Chloro-4,6-dimethylpyrimidine2×HCID 5817192-Chloro-5-methylpyrimidine

Product 1

HCID 59418303HCID 59418303, compound

Procedure

Compound P15 was prepared according to the general procedure described for the synthesis of P12 in Preparation 12, except that 2-chloro-4,6-dimethylpyrimidine (the synthesis of 2-chloro-4,6-dimethylpyrimidine is described by G. Vlad & I. T. Horvath, J. Organic Chem., 2002, 67, 6550-6552) was used instead of 2-chloro-5-methylpyrimidine, to provide P15. Yield: 345 mg, 2.11 mmol, 43%. 1H NMR (400 MHz, CD3OD) δ 2.44 (s, 6H), 4.00 (m, 2H), 4.14 (m, 3H), 7.12 (s, 1H).

Workup

  1. customCompound P15 was prepared
  2. customto provide P15

Sources & evidence

ORD record
ord-65b09b5c541747ad863229bbd8d52eb7
Source dataset
uspto-grants-2013_12
Patent number
US08618117B2

Reaction notes

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