Ethanol → HCID 58158130, compound

Participants

Reaction Steps

100 mg (0.602 mmol) of 4-(2-hydroxyethoxy)benzaldehyde, 76 mg (0.602 mmol) of 6-amino-1,2,3,4-tetrahydropyrimidine and 40 mg (0.602 mmol) of malononitrile were initially charged in 2 ml of ethanol, 0.13 ml (122 mg, 1.204 mmol) of 4-methylmorpholine was added and the mixture was stirred at reflux overnight. The reaction mixture was cooled, and about 20 ml of water were then added. The precipitate formed was filtered off and dried. The crude product was used without further purification for the subsequent reaction.

Provenance & Evidence