Sulfuric Acid → 4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole

Participants

Reaction Conditions

Reaction Steps

408 mg (3.21 mmol) of 1,3-dichloroacetone and 500 mg (3.21 mmol) of 4-chlorobenzamide were combined and stirred at 135° C. for 1 h. The mixture was then cooled to RT, 1.1 ml of conc. sulfuric acid were added carefully and the mixture was stirred for another 5 min. Carefully, the mixture was poured onto ice. The precipitate was filtered off and washed with water. After drying, the crude product was used without further purification for the subsequent reaction.

Provenance & Evidence