Ethyl orthoformate → HCID 44132886, compound

Participants

Reaction Steps

50 mg (0.10 mmol) of the compound from Example 15A, 113 mg (0.69 mmol) of triethyl orthoformate and 38 mg (0.50 mmol) of ammonium acetate were combined and reacted in a microwave at 160° C. for 10 min. After cooling to RT, the reaction was purified directly by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

Provenance & Evidence