Sodium Sulfide → HCID 44132889, compound

Participants

Reaction Steps

100 mg (0.229 mmol) of the compound from Example 11A were dissolved in 0.46 ml of DMF, 21 mg (0.274 mmol) of sodium sulfide were added and the mixture was stirred at RT overnight. 33 mg (0.137 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 23 mg (0.275 mmol) of sodium bicarbonate were then added, and the reaction solution was stirred at RT for 2 h. Water was added to the reaction mixture for further purification via a preparative HPLC (Chromasil, water/acetonitrile+0.1% TFA) purified.

Provenance & Evidence