Ammonium formate → HCID 178509462, compound

Participants

Reaction Steps

A solution of 2-amino-6-cyano-1H-indole-3-carboxylic acid ethyl ester (750 mg, 3.3 mmol) and ammonium formate (193 mg, 3.3 mmol) in 4 mL formamide was heated to 175° C. overnight. The reaction mixture was allowed to cool to room temperature then poured onto water. The resulting precipitate was collected by filtration to give 297 mg of the title compound as a black solid. 1H NMR (DMSO) δ 12.7 (1H, s, br), 12.5 (1H, s, br), 8.23 (1H, d, J=4), 8.10 (1H, d, J=8.1), 7.93 (1H, s), 7.61 (1H, dd, J=8.1, 1.4); LC-MS (1) Rt 1.12 min; m/z (ES−) 209.

Provenance & Evidence