Hydrochloric Acid → HCID 178518050, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-Amino-1H-pyrrolo[2,3-c]pyridine-3-carboxylic acid ethyl ester (1.80 g, 8.8 mmol) and ammonium formate (0.62 g, 9.8 mmol) in formamide (10 mL) was heated at 170° C. for 18 hours. 1 M HCl was added to the cooled reaction mixture and the resulting suspension was filtered to remove insolubles. The filtrate was then adjusted to pH 7 with saturated sodium bicarbonate solution. The resulting precipitate was collected by filtration and dried to a constant weight in a vacuum oven to give the title compound (0.74 g, 4.0 mmol). 1H NMR (DMSO) δ 12.5 (s, br), 8.83 (1H, s), 8.37 (1H, d, J=4.0), 8.26 (1H, s), 7.89 (1H, d, J=4.0); LC-MS (1) Rt 0.75 min; m/z 185 (ES−).

Provenance & Evidence