Formamide → HCID 178518049, compound

Participants

Reaction Conditions

Reaction Steps

2-Amino-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid ethyl ester (600 mg, 3 mmol) and ammonium formate (185 mg, 3 mmol) were suspended in 10 mL formamide and heated at 175° C. for 5 hours. Water was added to the cooled reaction mixture and the resulting precipitate collected and dried in vacuo. Unprecipitated product was recovered from the filtrate by using a MP-TsOH SPE cartridge and eluting with 7 N ammonia to give a combined mass of 330 mg of the title compound. LCMS (1): Rt 0.67 min; m/z 188 [M+H]+.

Provenance & Evidence