HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl chloroformate → HCID 67350493, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 6-Amino-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine | HCID 15633302 | — |
| Solvent | Propan-2-one--water (1/1) | HCID 18366337 | — |
| Product | HCID 67350493 | HCID 67350493 | 100% |
Reaction Steps
A solution of 2,3-dihydro-1,4-dioxino[2,3-b]pyridin-6-amine (commercial; 2.70 g) in acetone/water 1:1 (40 mL) was treated at 0° C. with 1M. NaHCO3 (35 mL) and CbzCl (2.63 mL). The reaction mixture was stirred at rt for 3 h, the org. solvent was evaporated under reduced pressure and the residue was partitioned between water and ether/EA. The org layer was dried over MgSO4 and evaporated under reduced pressure, affording a beige solid (5.3 g; 100% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618092B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-c51fd5d918024acdba8db028dbff7f09 |
| Source note | uspto-grants-2013_12 |